Explorer les evidences

13,8 yearsThe mean age at onset of pubic hair development (Tanner stage PH2) was 13.8 years in girls with sickle cell anaemia.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 7 observations

Nitric oxide scavenging (NOS) and superoxide dismutase (SOD) activities as well as glutathione level were significantly lower in sickle cell anaemia individuals compared to controls.

Nigeriadrépanocytosepublié 2021African health sciencesPubMeddocument de 7 observations

20 000 000 peopleSickle cell anaemia affects 20-25 million people globally.

Nigeriadrépanocytosepublié 2026Scientific reportsPubMeddocument de 7 observations

There is a disproportionately high incidence of sickle-cell disease in Nigeria.

Nigeriadrépanocytosepublié 2016Pharmacology research & perspectiveseurope_pmcdocument de 5 observations

17 deathsAll 17 deaths occurred among patients with lower respiratory diseases.

Nigeriadrépanocytose · lower respiratory diseasesobservé 2012 to 2021publié 2024PloS onePubMeddocument de 12 observations

6,6 %The caries experience of children with sickle-cell anaemia was 6.6% in the permanent dentition.

Nigeriacaries dentaires · drépanocytosepublié 2025BMC oral healthPubMeddocument de 8 observations

8 %Mean HbF level among HbSS participants was 8.0%.

Nigeriadrépanocytosepublié 2021West African journal of medicinePubMeddocument de 13 observations

96,2 %96.2% of study participants had good knowledge of what causes sickle cell disease.

Nigeriadrépanocytosepublié 2023Frontiers in geneticseurope_pmcdocument de 5 observationsDOI 10.3389/fgene.2023.1052444

359 patientsNorth East registered 359 patients with sickle cell disease, representing 4.6% of the total enrolled in Nigeria.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 8 observations

3 deathsA total of 3 deaths occurred in the moderate-dose hydroxyurea group.

Nigeriadrépanocytosepublié 2023BloodPubMeddocument de 8 observations

89,7 %Out of 378 participants, 339 (89.7%) were using hydroxyurea while 39 (10.3%) had stopped using hydroxyurea at the time of the study.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 10 observations

55 %Among 108 children who completed the feasibility trial for managing severe acute malnutrition in older children with sickle cell anemia in Nigeria, 55% (n = 59) had low food security and 34% (n = 37) had very low food security.

Nigeriadrépanocytose · malnutritionpublié 2025Pediatric blood & cancerPubMeddocument de 4 observations

88 %At the 10% threshold, 88% of the poorest quartile of sickle cell disease patients experienced catastrophic expenditure.

Nigeriadrépanocytosepublié 2022PloS onePubMeddocument de 5 observations

2,89 scoreThe mean Beck Hopelessness Scale (BHS) score was 2.89 among clinically stable Nigerian adults with sickle cell disease.

Nigeriadrépanocytosepublié 2020Nigerian journal of clinical practicePubMeddocument de 8 observations

23,7 mg/kg/dayThe minimum dose of hydroxyurea required to achieve significant decline in TCD velocities ranged from 15 to 31 mg/kg/day, with a mean of 23.7 mg/kg/day.

Nigeriadrépanocytosepublié 2021Pediatric blood & cancerPubMeddocument de 5 observations

23 patients23 had osteomyelitis.

Nigeriadrépanocytosepublié 2021Hematology (Amsterdam, Netherlands)PubMeddocument de 16 observations

130 childrenThe study included 130 children with sickle cell anaemia aged 2–16 years at National Hospital Abuja, Nigeria.

Nigeriadrépanocytosepublié 2021West African journal of medicinePubMeddocument de 5 observations

9 yearsThe mean age of the controls was 9.0 years with a standard deviation of 3.1 years.

Nigeriadrépanocytosepublié 2023Ghana medical journalPubMeddocument de 7 observations

0 %CAE had a specificity of 0% for identifying the AC genotype relative to PCR.

Nigeriadrépanocytosepublié 2021Global pediatric healtheurope_pmcdocument de 5 observations

12,2 %Only 96 (12.2%) of the 780 mothers were aware of comprehensive care for babies with sickle cell disease.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 5 observations

9,1 %Ten (9.1%) children with sickle cell disease had low serum iron status.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 8 observations

94 %Among 164 mothers of children with SCD in a southwestern state of Nigeria, 154 (94%) had encountered genetic counseling for SCD.

Nigeriadrépanocytosepublié 2020TheScientificWorldJournalPubMeddocument de 9 observations

70 %Lower respiratory disease was the most common respiratory entity among sickle cell disease patients, accounting for 70.0% of respiratory morbidities.

Nigeriadrépanocytose · lower respiratory diseaseobservé 2012 to 2021publié 2024PloS onePubMeddocument de 12 observations

1 %The prevalence of sickle cell anaemia in Nigeria is 1-3%.

Nigeriadrépanocytosepublié 2026Scientific reportsPubMeddocument de 7 observations

3,98 odds_ratioIn multivariate analysis, hydroxyurea use was associated with painful crisis with an odds ratio of 3.98.

NigeriadrépanocytosePubMeddocument de 10 observations