Explorer les evidences

87,4 %The proportion of pregnant women with a high level of knowledge about sickle cell disease significantly increased from 12.6% in the pre-test to 87.4% in the post-test (p = 0.015).

Nigeriadrépanocytosepublié 2024BMC pregnancy and childbirthPubMeddocument de 6 observations

35,1 g/dLMean corpuscular hemoglobin concentration (MCHC) in steady state subjects was 35.1 ± 43.4.

Nigeriadrépanocytosepublié 2022The Pan African medical journalPubMeddocument de 14 observations

87,3 fLMean corpuscular volume (MCV) in crisis state subjects was 87.3 ± 8.2.

Nigeriadrépanocytosepublié 2022The Pan African medical journalPubMeddocument de 14 observations

6 per_100_person-yearsThe incidence rates of recurrent strokes were 6.0 per 100 person-years in the moderate-dose hydroxyurea group.

Nigeriadrépanocytosepublié 2023BloodPubMeddocument de 8 observations

0,229 correlation_coefficientThere was a significant positive correlation between SCA disease severity and serum urea (r = 0.229; p = 0.035).

Nigeriadrépanocytosepublié 2023Malawi medical journal : the journal of Medical Association of MalawiPubMeddocument de 12 observations

2 crises_per_yearFrequency of crisis ranged from 0 to >10/year median of 2.

Nigeriadrépanocytosepublié 2021Hematology (Amsterdam, Netherlands)PubMeddocument de 16 observations

150 000 newbornsApproximately 150,000 newborns are affected by sickle cell disease yearly in Nigeria.

NigeriadrépanocytosePubMeddocument de 7 observations

370 per_1000Children with sickle cell disease born between 2003 and 2013 in Nigeria had about 370 excess under-5 deaths per 1000 livebirths compared to children with HbAA.

Nigeriadrépanocytoseobservé 2003–2013publié 2021The Lancet. Haematologyeurope_pmcdocument de 6 observations

Utility score in sickle cell disease was low, indicating a substantial impact of the disease on health-related quality of life.

Nigeriadrépanocytosepublié 2019PloS onePubMeddocument de 5 observations

2,5 %Sickle cell disease affects 2-3% of an estimated population of 160 million people in Nigeria.

Nigeriadrépanocytosepublié 2022West African journal of medicinePubMeddocument de 5 observations

86,3 %145 (86.3%) of the participants had improved PCV while using hydroxyurea.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 10 observations

8 subjectsGlobin analysis in 30 SCA subjects showed that eight had three alpha-globin genes.

Nigeriadrépanocytosepublié 1989African journal of medicine and medical scienceseurope_pmcdocument de 6 observations

101 participantsA total of 101 participants were randomly allocated to low-dose and moderate-dose hydroxyurea treatment groups.

Nigeriadrépanocytosepublié 2023BloodPubMeddocument de 8 observations

0,85 mmol/lThe mean serum magnesium of subjects in vaso-occlusive crisis was significantly higher compared to the steady state (0.85 ± 0.1 vs 0.83 ± 0.1 mmol/l, p = 0.032).

Nigeriadrépanocytosepublié 2025BMC pediatricsPubMeddocument de 3 observations

12 patients12 had cholelithiasis.

Nigeriadrépanocytosepublié 2021Hematology (Amsterdam, Netherlands)PubMeddocument de 16 observations

122 childrenFrom July 2017 to June 2019, 122 children with sickle cell disease were admitted to the emergency department for painful crises.

Nigeriadrépanocytoseobservé July 2017 to June 2019publié 2020Transactions of the Royal Society of Tropical Medicine and HygienePubMeddocument de 6 observations

33,3 %33.3% of the patients with sickle cell disease in the study had impaired ability to concentrate their urine.

NigeriadrépanocytosePubMeddocument de 7 observations

15,6 yearsThe mean age at menarche was 15.6 years for menstruating sickle cell disease patients.

Nigeriadrépanocytosepublié 2021Annals of African medicinePubMeddocument de 4 observations

31 patients31 had nephropathy.

Nigeriadrépanocytosepublié 2021Hematology (Amsterdam, Netherlands)PubMeddocument de 16 observations

29 %Among 172 children with sickle cell disease, 29% (50/172) had never been transfused or had less than two transfusions per lifetime.

Nigeriadrépanocytosepublié 2022British journal of haematologyPubMeddocument de 7 observations

4 000 000 peopleSickle cell anaemia affects about 4 million people across the globe.

Nigeriadrépanocytosepublié 2021Hematology (Amsterdam, Netherlands)PubMeddocument de 16 observations

16 umol/LThe median direct bilirubin level was 16.0 umol/L with an interquartile range of 11.3–29.0 umol/L.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 7 observations

50 %For HbAC phenotype, isoelectric focusing showed a positive predictive value (PPV) of 50%.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 23 observations

19,27 %Le Nigeria a une prévalence de drépanocytose de 19,27 %.

NigeriadrépanocytoseHAL · Unilimdocument de 75 observations

21,55 kg/m²Sickle cell patients had lower Body Mass Index (21.55 ± 3.51 vs 24.94 ± 4.56 kg/m², p=0.000).

Nigeriadrépanocytosepublié 2022West African journal of medicinePubMeddocument de 8 observations