Explorer les evidences

257 patientsA total of 257 patients with sickle cell anaemia (HbSS) were enrolled during the study period from January 2013 to April 2018.

Nigeriadrépanocytoseobservé January 2013 to April 2018publié 2021Hematology/oncology and stem cell therapyPubMeddocument de 6 observations

3,4 mg/LThe mean beta-2-microglobulin (β2-M) among SCA patients was 3.4 ± 1.2 mg/L.

Nigeriadrépanocytosepublié 2023Malawi medical journal : the journal of Medical Association of MalawiPubMeddocument de 12 observations

10 monthsTime to significant decline in transcranial Doppler (TCD) velocities ranged from 5 to 35 months, with a median of 10.0 months.

Nigeriadrépanocytosepublié 2021Pediatric blood & cancerPubMeddocument de 5 observations

0,5 odds_ratio_per_1_g_HbThe odds of having abnormal LV geometry decreased by 0.5 for every 1 g increase in Hb level.

Nigeriadrépanocytosepublié 2026BMC cardiovascular disordersPubMeddocument de 6 observations

8,01 cmSickle cell anemia subjects had a smaller mean splenic size than non-SCA subjects (8.01 cm ± 1.89 vs. 8.19 cm ± 1.61).

Nigeriadrépanocytosepublié 2023Nigerian journal of clinical practicePubMeddocument de 9 observations

0,2 %Standard HemoTypeSC identified 1 (0.2%) HbAC phenotypes among 511 newborns.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 23 observations

1,2 %The combined prevalence of sickle cell disease genotypes (HbSS and HbSC) remained stable at approximately 1.2% among Nigerian university students between 2015 and 2024.

Nigeriadrépanocytoseobservé 2015-2024PubMeddocument de 3 observations

31,2 %Thirty-four (31.2%) children with sickle cell disease had low transferrin status.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 8 observations

17 %Among 164 mothers of children with SCD in a southwestern state of Nigeria, 28 (17%) were willing to partake in prenatal SCD diagnosis.

Nigeriadrépanocytosepublié 2020TheScientificWorldJournalPubMeddocument de 9 observations

8,91 cmLeft kidney length was significantly greater in sickle cell anemia patients (8.91 ± 1.16 cm vs. 8.27 ± 1.30 cm).

Nigeriadrépanocytosepublié 2023Nigerian journal of clinical practicePubMeddocument de 9 observations

54,5 umol/LThe median serum bilirubin level was 54.5 umol/L with an interquartile range of 37.0–119.0 umol/L.

Nigeriadrépanocytosepublié 2023West African journal of medicinePubMeddocument de 7 observations

76 711 NGNThe median monthly economic burden for sickle cell disease patients was approximately N76,711 (US$385) per person.

Nigeriadrépanocytosepublié 2022PloS onePubMeddocument de 5 observations

4 %The pooled prevalence of sickle cell disease among Nigerian children and adolescents was 4.0%.

Nigeriadrépanocytosepublié 2025Systematic reviewsPubMeddocument de 7 observations

0,8 %The prevalence of SCD among the infant cohort was 0.8%.

Nigeriadrépanocytosepublié 2020PloS onePubMeddocument de 4 observations

265,95 ng/mlThe median red cell folate level in children with sickle cell anaemia during crisis was 265.95 ng/ml.

Nigeriadrépanocytosepublié 2022Malawi medical journal : the journal of Medical Association of MalawiPubMeddocument de 3 observations

45,4 %Alpha thalassemia was present at a prevalence of 45.4% in sickle cell disease patients.

Nigeriaalpha thalassemia · drépanocytosepublié 2022Mediterranean journal of hematology and infectious diseaseseurope_pmcdocument de 17 observationsDOI 10.4084/mjhid.2022.001

13,2 %In the study, 13.2% of children with sickle cell anaemia had proteinuria.

Nigeriadrépanocytosepublié 2024West African journal of medicinePubMeddocument de 9 observations

12,7 %Cholelithiasis was observed in 12.7% of the children.

Nigeriacholelithiasis · drépanocytosepublié 2021West African journal of medicinePubMeddocument de 10 observations

46 %In the phase 2 portion of the RISE UP trial, the haemoglobin response rate (≥1.0 g/dL increase from baseline in average haemoglobin concentration from week 10 through week 12) was 46% in the mitapivat 50 mg group.

Nigeriadrépanocytosepublié 2025The Lancet. Haematologyeurope_pmcdocument de 9 observations

A significant high proportion of children with sickle cell anemia had abnormal valvar dimension and left ventricular function above two standard deviations from the mean of the standard population compared to the control group.

Nigeriadrépanocytosepublié 2021Malawi medical journal : the journal of Medical Association of MalawiPubMeddocument de 3 observations

80 %Among 308 children with sickle cell disease in Nigeria, cerebral artery blood velocity was normal in 246 (80%), high in 14 (4.5%), and conditional in 48 (15.5%).

Nigeriadrépanocytosepublié 2023Archives of disease in childhoodPubMeddocument de 5 observations

70 %Sickle cell disease is one of the most common haemoglobinopathies worldwide, with up to 70% of global SCD annual births occurring in sub-Saharan Africa.

Nigeriadrépanocytosepublié 2022Current stem cell research & therapyeurope_pmcdocument de 2 observations

10,9 %Stunting was observed in 10.9% of subjects with sickle cell anemia.

Nigeriadrépanocytose · malnutritionpublié 2020Nigerian journal of clinical practicePubMeddocument de 9 observations

21,1 %Among 133 children with sickle cell disease, 28 (21.1%) had documented neurological manifestations.

Nigeriadrépanocytoseobservé March 2022 and February 2025PubMeddocument de 8 observations

62,5 %More than half (62.5%) of the participants had SCD crisis within six months.

Nigeriadrépanocytoseobservé six monthspublié 2020The Pan African medical journalPubMeddocument de 8 observations