Explorer les evidences

1 383 patientsNorth West registered 1,383 patients with sickle cell disease, representing 17.8% of the total enrolled in Nigeria.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 8 observations

4 timesThe estimated national average under-5 mortality for children with sickle cell disease born between 2003 and 2013 in Nigeria was 4.0 times higher than for children with HbAA.

Nigeriadrépanocytoseobservé 2003–2013publié 2021The Lancet. Haematologyeurope_pmcdocument de 6 observations

26,7 %26.7% of respondents expressed willingness to bear consequences related to sickle cell disease birth risk.

Nigeriadrépanocytosepublié 2025BMC public healthPubMeddocument de 6 observations

7 %Wasting (body mass index z-score<-2) had a prevalence of 7% in the UK ones.

Nigeriadrépanocytosepublié 2019ThoraxPubMeddocument de 7 observations

19,6 %Standard HemoTypeSC identified 100 (19.6%) HbAS phenotypes among 511 newborns.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 23 observations

22,5 %Microalbuminuria was detected in 22.5% of sickle cell anaemia patients in the study cohort.

Nigeriadrépanocytosepublié 2020West African journal of medicinePubMeddocument de 4 observations

18,1 %Among patients with sickle cell anaemia in steady state, the prevalence of relative systemic hypertension was 18.1%.

Nigeriadrépanocytosepublié 2020Indian heart journalPubMeddocument de 3 observations

8,8 %The predicted CYP2D6 phenotype distribution among 503 Nigerian SCD patients was 8.8% Ultrarapid Metabolizers (UM), 54.1% Normal Metabolizers (NM), 26.0% Intermediate Metabolizers (IM), and 1.8% Poor Metabolizers (PM), with 9.3% undetermined.

Nigeriadrépanocytosepublié 2025Gates open researchPubMeddocument de 5 observations

79 %Standard HemoTypeSC identified 404 (79.0%) HbAA, 100 (19.6%) HbAS, 6 (1.2%) HbSS, and 1 (0.2%) HbAC phenotypes among 511 newborns.

Nigeriadrépanocytosepublié 2022Frontiers in geneticseurope_pmcdocument de 23 observations

No significant association was observed with the mutant genotypes MTR 2756 AG/GG and disease severity (p>0.05).

Nigeriadrépanocytosepublié 2022West African journal of medicinePubMeddocument de 5 observations

1,8 %In the study, 1.8% of children with sickle cell anaemia had elevated blood pressure.

Nigeriadrépanocytosepublié 2024West African journal of medicinePubMeddocument de 9 observations

2,2 %Among children with postneonatal risk factors for cerebral palsy, sickle cell disease was present in 3 out of 140 (2.2%).

Nigeriacerebral palsy · drépanocytosepublié 2020Archives of disease in childhoodPubMeddocument de 27 observations

6,8 g/dLThe mean ± SD haemoglobin level was 6.8 ± 1.6 g/dL for pediatric sickle cell anaemia patients in crisis.

Nigeriadrépanocytoseobservé 2023publié 2025BMC pediatricsPubMeddocument de 16 observations

6 %Recent screening-based studies suggest a β-thalassaemia trait prevalence of 6% to 10% among individuals with sickle cell disease (SCD) in Africa.

Nigeriadrépanocytose · β-thalassaemiapublié 2026African journal of laboratory medicineeurope_pmcdocument de 5 observations

The artherogenic index of plasma (AIP) in sickle cell anaemia patients ranges from -0.62 to 1.32.

Nigeriadrépanocytosepublié 2019The Pan African medical journalPubMeddocument de 4 observations

86 %Infant screening for SCD was acceptable to 86% of mothers presenting to the immunization clinics.

Nigeriadrépanocytosepublié 2020PloS onePubMeddocument de 4 observations

HbF and F cell parameters show significant association with transfusion rates, frequency of painful crises and episodes of febrile illness in individuals with sickle cell disease.

Nigeriadrépanocytosepublié 2025Communications medicineeurope_pmcdocument de 4 observations

17,9 %Bio-physiological factors explained 17.9% of the variance in utility score in people with sickle cell disease.

Nigeriadrépanocytosepublié 2019PloS onePubMeddocument de 5 observations

0,5 z_scoreNigerian SCA patients (n=154) had significant reductions in both FEV and FVC of ~0.5 z-scores compared with the UK patients (n=101).

Nigeriadrépanocytosepublié 2019ThoraxPubMeddocument de 7 observations

51 casesBetween July 14, 2017, and September 3, 2019, 51 (1%) children with sickle cell anaemia (HbSS) were identified among 3603 newborn babies and infants screened for sickle cell disease at five primary health-care centres.

Nigeriadrépanocytoseobservé July 14, 2017 to September 3, 2019publié 2020The Lancet. Haematologyeurope_pmcdocument de 3 observations

6,29 odds_ratioIn multivariate analysis, ciklavit use was associated with painful crisis with an odds ratio of 6.29.

NigeriadrépanocytosePubMeddocument de 10 observations

76,9 %Among male patients with sickle cell disease in Ibadan, Nigeria, who experienced priapism, 76.9% developed mild psychosocial experiences, especially fear of recurrence (56.4%) and sleeplessness (43.6%).

Nigeriadrépanocytosepublié 2020West African journal of medicinePubMeddocument de 9 observations

The fractional excretion of potassium was elevated in all patients with sickle cell disease.

Nigeriadrépanocytosepublié 2024The Nigerian postgraduate medical journalPubMeddocument de 10 observations

61,4 %61.4% of the 503 SCD patients were female.

Nigeriadrépanocytosepublié 2025Gates open researchPubMeddocument de 5 observations

93,3 %After a health education session, 93.3% of pregnant women understood that sickle cell disease can be diagnosed shortly after birth, compared to 43.9% before the session.

Nigeriadrépanocytosepublié 2024BMC pregnancy and childbirthPubMeddocument de 6 observations