Explorer les evidences

97,3 %At day 28, the PCR-adjusted efficacy of dihydroartemisinin-piperaquine was 97.3%.

Gabonpaludismepublié 2011PLoS medicineeurope_pmcdocument de 15 observations

8 patients8 of 545 patients in the paediatric formulation groups experienced drug-related gastrointestinal disorders.

Gabonpaludismepublié 2010The Lancet. Infectious diseaseseurope_pmcdocument de 6 observations

1 280 parasites/μLLa densité médiane du parasite du paludisme à forme asexuée chez les enfants positifs pour Plasmodium spp. était de 1280 parasites/μL dans le groupe APOE Ɛ4, avec un intervalle interquartile de [341–3680].

GabonpaludismeHAL · Unilimdocument de 81 observations

80 casesAmong 367 children enrolled, 80 (22.22%) were confirmed to be positive for malaria.

Gabonpaludismepublié 2023Diagnostics (Basel, Switzerland)europe_pmcdocument de 4 observationsDOI 10.3390/diagnostics13203271

66,7 %Adverse events of any cause occurred in 66.7% (24/36) of patients receiving 400 mg ferroquine plus 600 mg artefenomel.

Gabonpaludismepublié 2023Malaria journaleurope_pmcdocument de 13 observations

2 patientsTreatment with artesunate-fosmidomycin was associated with transient grade II neutropenia (absolute neutrophil counts of 400 to 749/μL) in two patients.

Gabonpaludismepublié 2005Antimicrobial agents and chemotherapyeurope_pmcdocument de 6 observations

Les densités parasitaires médianes étaient significativement plus élevées chez les enfants porteurs de l’allèle APOE Ɛ4 pour les densités de Plasmodium spp. par rapport aux enfants non porteurs d’APOE Ɛ4.

GabonpaludismeHAL · Unilimdocument de 81 observations

46,7 nMEx vivo chloroquine susceptibility data revealed a stepwise decrease in the median chloroquine IC50 from 46.7 nM in 2009 to 2.1 nM in 2024 in Lambaréné, Gabon.

Gabonpaludismeobservé 2009publié 2026International journal of molecular scienceseurope_pmcdocument de 6 observations

16 %The YFD haplotype was present in 16.0% of samples from Franceville.

Gabonpaludismepublié 2016Malaria journaleurope_pmcdocument de 25 observations

5 %In a post-hoc analysis, overall malaria infection was detected in 14 (5%) of 311 women in the intervention group and 31 (10%) of 320 women in the control group.

Gabonpaludismepublié 2024The Lancet. Infectious diseasesPubMeddocument de 6 observations

25 %Jaundice was present in 25% of severe malaria patients on admission.

Gabonpaludismepublié 2023Malaria JournalOpenAlexdocument de 25 observationsDOI 10.1186/s12936-023-04512-7

69,5 %Moderate to severe anaemia predominated among those single-infected with P. falciparum at a rate of 69.5%.

Gabonmoderate to severe anaemia · paludismeobservé 2015–2016publié 2020Transactions of the Royal Society of Tropical Medicine and Hygieneeurope_pmcdocument de 18 observations

4 %The prevalence of Plasmodium falciparum in savannah was 4%.

Gabonpaludismepublié 2011Malaria JournalOpenAlexdocument de 10 observationsDOI 10.1186/1475-2875-10-33

Fosmidomycin plus clindamycin was generally well tolerated in pediatric outpatients aged 1 to 14 years with uncomplicated Plasmodium falciparum malaria.

Gabonpaludismepublié 2006Antimicrobial agents and chemotherapyeurope_pmcdocument de 8 observations

14,3 %Repeated seizures occurred in 14.3% of PLHIV with malaria.

Gabonpaludisme · VIH/sidaobservé 2021 to 2022publié 2026PloS onePubMeddocument de 11 observations

1,91 adjusted_odds_ratioParticipants presenting during high transmission seasons were at significantly higher risk for P. falciparum infection compared to low transmission seasons, with an adjusted odds ratio of 1.91.

Gabonpaludismeobservé 2008–2011publié 2013Malaria JournalOpenAlexdocument de 6 observationsDOI 10.1186/1475-2875-12-412

497 individualsA total of 497 afebrile males were screened during a period of one year to investigate the prevalence of asymptomatic Plasmodium falciparum parasitemia in villages near Lambaréné, Gabon.

Gabonpaludismeobservé one yearpublié 2007The American journal of tropical medicine and hygieneeurope_pmcdocument de 4 observationsDOI 10.4269/ajtmh.2007.77.939

19,35 %In urban areas, the prevalence of Plasmodium sp. infection was 19.35% among 491 participants in south-east Gabon between April and July 2022.

Gabonpaludismeobservé April and July 2022publié 2024Journal of parasitology researcheurope_pmcdocument de 5 observations

The frequency of wild type allele pfcrt K76 or pfmdr1 N86 was higher among patients without antimalarial drug self-medication compared to those who used it.

Gabonpaludismepublié 2014Transactions of the Royal Society of Tropical Medicine and Hygieneeurope_pmcdocument de 5 observations

93,97 %93.97% of Plasmodium sp. infections in rural areas were asymptomatic in south-east Gabon between April and July 2022.

Gabonpaludismeobservé April and July 2022publié 2024Journal of parasitology researcheurope_pmcdocument de 5 observations

30 hoursMedian time to parasite clearance was 30.0 hours with ferroquine/artefenomel combination.

Gabonpaludismepublié 2023Malaria journaleurope_pmcdocument de 13 observations

23 %14 (23%) of 63 placebo recipients became thick blood smear-positive for Plasmodium falciparum at 2–26 weeks after vaccination.

Gabonpaludismepublié 2026The Lancet. Infectious diseasesPubMeddocument de 8 observations

98 nMCompound 6i demonstrated potent activity against asexual blood-stage Plasmodium falciparum parasites with an IC50 of 98 nM against the PfDd2 strain.

Gabonpaludismepublié 2024European journal of medicinal chemistryPubMeddocument de 5 observations

92 %In part A, the PCR-corrected adequate clinical and parasitological response at day 29 was 92% (95% CI 81–98) for the 1-day regimen of ganaplacide 400 mg plus lumefantrine-SDF 960 mg.

Gabonpaludismepublié 2023The Lancet. Infectious diseasesPubMeddocument de 10 observations

53,4 %La prévalence de Plasmodium spp. était de 53,4 % chez les enfants âgés de 5 à 9 ans.

GabonpaludismeHAL · Unilimdocument de 81 observations