Gold tier: mechanically validated evidence, with its primary source.
682 evidence items · page 4 / 28
3,603 individualsA total of 3603 newborn babies and infants younger than 9 months were screened for sickle cell disease at five primary health-care centres between July 14, 2017, and September 3, 2019.
Nigeriadrépanocytoseobserved July 14, 2017 to September 3, 2019published 2020The Lancet. Haematologyeurope_pmcdocument of 3 observations
82.4 %Twenty-eight (82.4%) SCA children had elevated serum cTnT during VOC.
Nigeriadrépanocytosepublished 2020Paediatrics and international child healtheurope_pmcdocument of 8 observations
99.2 %Among SCD patients, 130 (99.2%) were extensive metabolizers and 1 (0.8%) was a poor metabolizer of proguanil.
Nigeriadrépanocytosepublished 2016Pharmacology research & perspectiveseurope_pmcdocument of 5 observations
48.9 %ECG abnormalities were recorded in 22 out of 45 (48.9%) pediatric sickle cell anaemia patients in steady state.
Nigeriadrépanocytoseobserved 2023published 2025BMC pediatricsPubMeddocument of 16 observations
2.3 %Among the 88 high-risk staff, 2.3% had sickle cell disease.
Nigeriadrépanocytosepublished 2020The Pan African medical journalPubMeddocument of 11 observations
148 patientsOf the 219 recorded, 148 of the patients had been transfused in the past.
Nigeriadrépanocytosepublished 2021Hematology (Amsterdam, Netherlands)PubMeddocument of 16 observations
0.7 %Liver cirrhosis was observed in 0.7% of the children.
Nigeriadrépanocytose · liver cirrhosispublished 2021West African journal of medicinePubMeddocument of 10 observations
31.7 %The overall return rate for acute care within 1 week for either persistence of symptoms or any other complaint among children with sickle cell disease managed by short-term emergency department observation care was 31.7%.
Nigeriadrépanocytoseobserved July 2017 to June 2019published 2020Transactions of the Royal Society of Tropical Medicine and HygienePubMeddocument of 6 observations
6.8 %Stroke occurred in 6.8% of the 133 children with sickle cell disease.
NigeriaAVC · drépanocytoseobserved March 2022 and February 2025PubMeddocument of 8 observations
98.2 %The diagnostic specificity of SickleSCAN™ for sickle cell disease (Hb SS and Hb SC) was 98.2%.
Nigeriadrépanocytosepublished 2017Hemoglobineurope_pmcdocument of 5 observations
3.8 %Among 26 alloimmunized sickle cell disease participants, MNS alloantibodies were observed in 3.8%.
Nigeriadrépanocytose · MNS alloantibodiespublished 2025Transfusion and apheresis science : official journal of the World Apheresis Association : europe_pmcdocument of 9 observations
50 %The number of subjects who had more than two episodes of painful crises reduced from 27 (50%) to 2 (2.7%) after 12 months of hydroxyurea therapy.
Nigeriadrépanocytosepublished 2020Journal of tropical pediatricsPubMeddocument of 4 observations
7 x10⁹/LAbsolute neutrophil count in steady state subjects was 7.0 ± 2.1.
Nigeriadrépanocytosepublished 2022The Pan African medical journalPubMeddocument of 14 observations
17.6 %Serum cTnT was elevated in six (17.6%) SCA children during the steady state.
Nigeriadrépanocytosepublished 2020Paediatrics and international child healtheurope_pmcdocument of 8 observations
28.24 mmThe mean trans annular plane systolic excursion (TAPSE) in children with sickle cell anaemia was 28.24 ± 5.23 mm.
Nigeriadrépanocytosepublished 2020BMC pediatricsPubMeddocument of 8 observations
72.5 %The majority (72.5%) of the SCD participants had received at least 1 unit of red blood cell transfusion in their lifetime.
Nigeriadrépanocytosepublished 2021ImmunohematologyPubMeddocument of 7 observations
In a randomized controlled trial in southwest Nigeria, low-dose aspirin (100 mg daily) did not significantly reduce the composite primary outcome of intrauterine growth restriction, perinatal mortality, or miscarriage in pregnant women with haemoglobin SS or SC.
Nigeriadrépanocytosepublished 2026The Lancet. Global healthPubMeddocument of 13 observations
78 %A significantly higher proportion of children with sickle cell disease (78%) had high ferritin status compared with controls (48.3%).
Nigeriadrépanocytosepublished 2023West African journal of medicinePubMeddocument of 8 observations
73 %Seventy-three percent of the respondents noted that hydroxyurea reduced transfusion rates in patients with sickle cell disease.
Nigeriadrépanocytosepublished 2019HemoglobinPubMeddocument of 7 observations
29.2 %Among 209 parents of children with SCD in Ibadan, Nigeria, 29.2% discovered their sickle cell phenotype only after having a child with SCD or during a health crisis.
Nigeriadrépanocytosepublished 2025BMC public healthPubMeddocument of 5 observations
0.07 kappaMeasures of agreement between ECG and cTnT in detecting myocardial injury were poor during VOC (κ 0.07, p = 0.68).
Nigeriadrépanocytosepublished 2020Paediatrics and international child healtheurope_pmcdocument of 8 observations
6 %Among 3622 enrolled sickle cell disease patients in Nigeria, 6.0% had avascular necrosis of bone.
Nigeriaavascular necrosis of bone · drépanocytosepublished 2020Blood cells, molecules & diseaseseurope_pmcdocument of 16 observations
39 %At the end of the trial, 39% of participants improved their body mass index z score to ≥-3.0.
Nigeriadrépanocytosepublished 2023Blood advancesPubMeddocument of 6 observations
515,000 birthsGlobally, approximately 515000 babies are born with sickle cell disease annually.
Nigeriadrépanocytosepublished 2024BMJ openeurope_pmcdocument of 2 observations
5,295 patients5,295 people living with sickle cell disease had at least one follow-up visit with their clinical data updated.
Nigeriadrépanocytosepublished 2022Frontiers in geneticseurope_pmcdocument of 8 observations
Every row leads to its source document. The figure shown counts the VALIDATED observations it carries, never the extracted ones: the two differ on most documents. The exact source excerpt is not published, due to copyright constraints.